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インターネット経由でxamlを取得する例とcs側でボタンを追加する例です。
あとは、こんな感じでIronPythonなどのスクリプト言語と接続できればいいのですが。

using System;

using System.Collections.Generic;

using System.Text;

using System.Xml;

using System.IO;

using System.Net;

using System.Windows;

using System.Windows.Markup;

using System.Windows.Controls;

using System.Windows.Data;

using System.Windows.Media;

using System.Windows.Media.Animation;

using System.Windows.Navigation;
namespace ConsoleApplication1

{

    class Program

    {

        [STAThread]

        static void Main(string[] args)

        {            

            // http経由でxamlを受け取る場合			

            System.Net.WebClient client = new WebClient();

            Byte [] data = client.DownloadData( "http://localhost/Window1.xaml" );

            MemoryStream st = new MemoryStream( data );            

            

            // Stream st = File.OpenRead( @"E:\work_blend\test\Window1.xaml" );

            

            Window mainwnd = (Window)XamlReader.Load( st );

            mainwnd.Height = 480;

            mainwnd.Width = 640;

            mainwnd.Title = "hoi";

            

            

            Button btn = (Button)mainwnd.FindName( "button1" );

            btn.Click += new RoutedEventHandler(btn_Click);

        

        

            Button btn2 = new Button();

            btn2.Click += new RoutedEventHandler(btn_Click2);

            btn2.Name = "button2";

            btn2.Width = 100;

            btn2.Height = 40;

            btn2.Content = "ボタン２";

            

            Grid grid  = (Grid)mainwnd.FindName( "grid1" );

            grid.Children.Add( btn2 );

    

            Application ap = new Application();

            ap.Run( mainwnd );

            

        }
        static void btn_Click(object sender, RoutedEventArgs e)

        {

            MessageBox.Show( "ok" );

        }

        static void btn_Click2(object sender, RoutedEventArgs e)

        {

            MessageBox.Show( (string)((Button)sender).Content );

        }

        

    }

}